Getting his first start for the Manu is Bay of Plenty prop Jordan Lay.
Lay's brother James is on the bench and will make his debut if gets on the field.
The other two changes sees young hooker Elia Elia get a start and experienced flanker Jack Lam returns from injury.
RNZI reports the backline remains unchanged.
Head Coach Namulauulu Alama Ieremia said he has selected a team he believes can counter a strong Fijian side that will be full of confidence.
"We have had a couple of disruptions with players in and out, but the team has continued seamlessly with its preparations this week.
"The entire squad have rallied together strongly to ensure we can put our best performance forward after our narrow loss against Tonga," he said.
Namulauulu said the team has gone about their work quietly understanding the enormity and significance of the game.
"We are clear on the requirements to get a much needed result, so it's the process and preparation that is our absolute focus against a very good Fijian side."
The full Samoa team is:
Jordan Lay, Elia Elia, Paul Alo-Emile, Chris Vui, Faatiga Lemalu, Piula Faasalele, Jack Lam, Faifili Levave, Kahn Fotualii, Tusiata Pisi, David Lemi (c), Reynold Lee-Lo, Kieron Fonotia, Alapati Leiua, Tim Nanai Williams.
Reserves: Seilala Lam, Nephi Leatigaga, James Lay, Galu Taufale, Vavae Tuilagi, Auvasa Falealii, D'Angelo Leuila, Ahsee Tuala.
Brothers James and Jordan Lay. Photo: Samoa Rugby Union / Wayne Dowd