Bristol's difficult start to life back in the top tier continued at the Ricoh Arena, where ruthless Wasps turned on the style and ran in 10 tries to join Bath and champions Saracens on 14 points.
Brilliant Wasps had the bonus point in the bag at half-time, with Tommy Taylor touching down off the back of a driving maul in the first minute as Bristol were swept aside on Sunday.
Elliot Daly, Jake Cooper-Woolley, Matt Symons and Christian Wade also went over in the first half as Wasps opened up a commanding 37-3 advantage at the break.
Rapid winger Wade, centre Daly and Ashley Johnson helped themselves to doubles, while Jimmy Gopperth landed 20 points from the tee as Wasps put on a masterclass.
Jack Lam, Mitch Eadie and Gaston Cortes scored second-half tries for a Bristol side who have claimed only one point from their first three games, while Wasps came within a whisker of bettering the club record 71-7 Premiership victory they set against London Welsh two years ago.
Leicester Tigers edged out Newcastle Falcons 14-13 at Kingston Park in the other Premiership game of the day.
A Juan Pablo Socino try and five points from the boot of Mike Delany put the Falcons 10-0 up with 16 minutes played, but Mike Fitzgerald claimed the Tigers' solitary try and Freddie Burns landed three penalties as Leicester made it two wins from three.
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