The Mooloos have followed up their opening 53-28 win over Wellington with a bonus point 41-19 victory over North Harbour, also in Hamilton.
Harbour were never able to recover after falling 26-nil behind inside half an hour.
The visitors did score the last two tries of the first half to cut the deficit to 29-12 at halftime, but Waikato managed to keep North Harbour at bay in the second 40.
Waikato halfback Xavier Roe scored a first-half double, while Quinn Tupaea, Mitch Jacobson, Damian McKenzie and Valynce Te Whare also dotted down for the Mooloos.
Luteru Tolai, Jacob Pierce and Lewis Gjaltema scored North Harbour's tries.