The duo could return from injury, having been sidelined for the chastening loss to France in England's Six Nations opener.
Eddie Jones, who will name his 23-man matchday selection on Thursday, has cut Charlie Ewels and will be without injured duo Manu Tuilagi (groin) and Anthony Watson (calf).
Lock Launchbury is on the mend following a knee problem, while Vunipola missed the clash in Paris after suffering an issue with his eye.
Bath second row Ewels was substituted in the second half against France, when England were 24-0 down. They went on to claim a losing bonus point in a 24-17 defeat.
— England Rugby (@EnglandRugby) February 5, 2020
Forwards: Luke Cowan-Dickie, Tom Curry, Ben Earl, Ellis Genge, Jamie George, Maro Itoje, George Kruis, Joe Launchbury, Courtney Lawes, Lewis Ludlam, Joe Marler, Kyle Sinckler, Will Stuart, Sam Underhill, Mako Vunipola
Backs: Elliot Daly, Ollie Devoto, Owen Farrell, George Ford, George Furbank, Willi Heinz, Jonathan Joseph, Jonny May, Ollie Thorley, Ben Youngs
Photo Getty Images Caption: Joe Launchbury dominates the line-out