In-form number eight Dombrandt did not make the matchday squad for the defeat to France in Paris on Sunday despite Billy Vunipola being ruled out with a broken arm.
Tom Curry was instead shifted to the back of the pack for the game at the Stade de France, with France running out 24-17 winners.
Dombrandt, who plays his club rugby for Harlequins, has not been included for the Calcutta Cup clash at Murrayfield.
Tuilagi is on the list of players, however, even though he suffered a groin injury in Paris, leading to him being substituted in the first half.
The uncapped Tom Dunn, Ben Earl, Alex Moon, Fraser Dingwall, Ollie Thorley and Jacob Umaga were also selected by Jones.
Forwards: Luke Cowan-Dickie, Tom Curry, Tom Dunn, Ben Earl, Charlie Ewels, Ellis Genge, Jamie George, Ted Hill, Maro Itoje, George Kruis, Joe Launchbury, Courtney Lawes, Lewis Ludlam, Joe Marler, Alex Moon, Kyle Sinckler, Will Stuart, Sam Underhill, Mako Vunipola, Harry Williams.
Backs: Elliot Daly, Ollie Devoto, Fraser Dingwall, Owen Farrell, George Ford, George Furbank, Willi Heinz, Jonathan Joseph, Jonny May, Ollie Thorley, Manu Tuilagi, Jacob Umaga, Anthony Watson, Ben Youngs.
Photo Getty Images Caption: Harlequins number eight Alex Dombrandt