Just two main draw singles matches were completed on the first day, with a number of qualifying also still to be completed.
22-time grand slam winner Williams will play Frenchwoman Pauline Parmentier first up before Naomi Osaka resumes her match with Annika Beck of Germany with the Japanese player a set up.
The New Zealand number one Marina Erakovic will then play seventh seed Jelena Ostapenko of Latvia, before third seed Caroline Wozniacki opens her campaign against Nicolle Gibbs of the United States.
In the night session 18 year old national champion Jade Lewis plays second seed Venus Williams.
ORDER OF PLAY - TUESDAY, JANUARY 03, 2017
CENTRE COURT start 12:30 pm
S. Williams (USA) vs P. Parmentier (FRA)
A. Beck (GER) vs N. Osaka (JPN) 26 12
[WC] M. Erakovic (NZL) vs J. Ostapenko (LAT)
N. Gibbs (USA) vs C. Wozniacki (DEN)
Not Before 6:30 pm
[WC] J. Lewis (NZL) vs V. Williams (USA)
A. Pavlyuchenkova (RUS) vs J. Goerges (GER)
GRANDSTAND start 12:30 pm
B. Strycova (CZE) vs B. Stefkova (CZE)
L. Davis (USA) vs K. Bertens (NED) 35
Y. Wickmayer (BEL) vs J. Larsson (SWE)
A. Konjuh (CRO) vs K. Flipkens (BEL)
N. Broady (GBR) vs D. Kovinic (MNE)
COURT 2 start 12:30 pm
Qualifying - N. Hibino (JPN) vs A. Rodionova (AUS) 36 76(3) 23
M. Barthel (GER) vs M. Lucic-Baroni (CRO)
J. Loeb (USA) vs M. Brengle (USA)
Qualifier vs V. Lepchenko (USA)
Not Before 5:00 pm
T. Maria (GER) / N. Melichar (USA) vs D. Schuurs (NED) / R. Voracova (CZE)
Photo: PHOTOSPORT / 123RF Serena Williams