The president will travel to three of Taiwan's six allies in the region, Tuvalu, the Marshall Islands and Solomon Islands.
Other countries recognise China instead of Taiwan in line with China's "One China" policy.
A professor of international relations at Auckland University Stephen Hoadley said President Tsai is trying to shore up relations with the Pacific bloc to prevent her country from becoming diplomatically isolated.
"This would certainly sweeten the feeling in the Pacific islands," Mr Hoadley said.
