Autonomous-driving firm Waymo's cars have been going up and down the cul-de-sac at all hours "for weeks", according to local news station KPIX.
Residents say vehicles sometimes have to queue before making multi-point turns to leave the way they came.
Waymo says the vehicles are just "obeying road rules" designed to limit traffic in certain residential streets.
"There are some days where it can be up to 50," Jennifer King told KPIX. "It's literally every five minutes. And we're all working from home, so this is what we hear."
She said the human "safety drivers" supervising the automated cars "don't have much to say other than the car is programmed and they're just doing their job".
A spokesman for Waymo said the cars sometimes made a detour because of the presence nearby of one of San Francisco's "slow streets", which aim to limit traffic in certain residential areas.
"We continually adjust to dynamic San Francisco road rules. In this case, cars travelling north of California on 15th Avenue have to take a u-turn due to the presence of 'slow streets' signage on Lake," the company said.