It said any videos that contradict expert consensus from local health authorities, such as the NHS or World Health Organization, will be removed.
It follows an announcement by Facebook that it would ban ads that discourage people from getting vaccinated.
However, that restriction will not apply to unpaid posts or comments.
YouTube had already banned "medically unsubstantiated" claims relating to coronavirus on its platform.
But it is now explicitly expanding the policy to include content relating to vaccines.