The Disney blockbuster has become the fastest film ever to break the $1bn barrier, doing so in just five days.
Endgame is the 22nd offering in the Marvel Studios superhero franchise.
Its opening takings smashed the previous global debut record of $640m set by last year's Avengers: Infinity War.
In the US alone, Endgame - which stars Robert Downey Jr as Iron Man - brought in a record $350m, and also enjoyed the UK and Ireland's biggest opening ever with takings of £43.7m.