Wing Moodie scored two tries in the 52-16 win over Wales in Cardiff at the weekend but will move to a less familiar role at outside centre in place of Jesse Kriel, who also got a brace in that game.
He has not played centre since schoolboy level.
The injury absence of stalwart Lukhanyo Am means 20-year-old Moodie will provide cover at 13 for the Springboks.
He will partner Andre Esterhuizen in the midfield, with Damian Willemse, showing no ill-effects of his clash of heads with Wales wing Rio Dyer, starting in the fullback position.
