The island, with a population of about 1500, has now vaccinated almost 100 percent of its target group.
Stuff reports a national celebration was held on Tuesday to mark the vaccination milestone.
With Pfizer vaccines supplied by New Zealand, Niue began its vaccination programme on June 1 and vaccinated 97 per cent of the eligible population on the first round.
The second round went smoothly and achieved the same results, with vaccinations completed on July 9.
Niue's government is looking to vaccinate those aged 12-15, once it gets the go-ahead from MedSafe.