"There's a video out there promoting some dental plan with an AI version of me," the actor wrote on Instagram.
"I have nothing to do with it," he added.
Hanks has previously spoken about the "artistic challenge" that AI poses his industry, and the issue has been central to recent strikes by high-profile Hollywood actors and writers.
As AI systems have grown in power and sophistication, so have concerns about their ability to create ever more realistic virtual versions of real people - what are sometimes called deepfakes.
