Anthony Watson

Leicester's Watson replaces the injured Ollie Hassell-Collins on the wing in the only change to the starting XV that beat Italy in round two.

Vice-captain Courtney Lawes is set for his first England appearance since July having been named on the bench.

Ben Curry is also a replacement after being called into the squad when brother Tom was injured.

With the experienced Jonny May and Jack Nowell left out of new head coach Steve Borthwick's original Six Nations squad, Hassell-Collins led the way for a new generation to shine.

Vunipola has been out since December with a knee injury and had been expected to return for the Twickenham clash on February 26.

That now appears unlikely, although he could feature for Saracens when they take on Gloucester in the Aviva Premiership on Friday as he looks to prove his fitness.

Northampton prop Paul Hill has therefore been retained but Wasps' Matt Mullan has been left out.