Her new superhero movie has been delayed three times during the coronavirus pandemic.
Jenkins is among dozens of top Hollywood directors appealing to the US government to provide a financial lifeline to cinemas.
Her warning comes as cinemas in the UK are also struggling with a recent spate of delayed film releases.
"If we shut this down, this will not be a reversible process," she said in an interview with Reuters news agency. "We could lose movie theatre-going forever."