Hundreds of fans gathered to watch on a big screen in Melbourne - the city where the show is set and produced.
The finale will air in New Zealand in September, while in the UK, where Neighbours found most success, it will be broadcast on Friday.
Former stars of the show including Kylie Minogue, Jason Donovan, Guy Pearce and Margot Robbie returned to say goodbye to Ramsay Street.
Over almost 37 years, the soap has had plane crashes, bushfires, drownings, and several tearful bedside death scenes.
