Warren Galtand's tourists face the Super Rugby franchise in Dunedin on the back of tackling the competition's dominant force, Crusaders, and beating them 12-3 on Saturday.
Returning captain Warburton has not played the last two fixtures due to an ankle injury, while Biggar sat out the Crusaders win due to concussion.
The skipper is joined by James Haskell and CJ Stander in the back row, while Iain Henderson replaces Maro Itoje at lock from the Lions' last midweek match - a 22-16 defeat to Blues - to partner Courtney Lawes.
