Moore has opted to give up the captaincy immediately and will step down from Test rugby after this year's Spring Tour and will play just one more season of Super Rugby, with Queensland, despite having two years to run on his deal.
Moore, 34, is the second-most capped Wallabies player of all time and captained the team to a World Cup final in 2015.
Currently in the first of that three-year deal with the Reds and the ARU, the Wallabies skipper had set the target of playing in the 2019 tournament, likely becoming the most-capped Wallaby along the way.
